The grid block is the most basic building block and works as a traditional spreadsheet made up of cells. Once you've created a grid block, name the block to stay organized and then start inputting data like you would in any spreadsheet.
Organize your data however makes sense to you, but since you are working with an endless canvas that can hold unlimited grid blocks, our recommended best practice is to separate your analysis into multiple parts, such as inputs and outputs in different grids.